Limbinė sistema (tiksliau migdolas (angliškai amygdala) ir hipokampas dalyvauja religinių vizijų ir haliucinacijų procese. Pašalinus migdolus ir hipokampą net LSD nustoja sukelti haliucinacijas.
"As is well known, LSD can elicit profound hallucinations involving all spheres of experience. Following the administration of LSD high amplitude slow waves (theta) and bursts of paroxysmal spike discharges occurs in the hippocampus and amygdala (Chapman & Walter, 1965; Chapman et al. 1963), but with little cortical abnormal activity. In both humans and chimps, when the temporal lobes, amygdala and hippocampus are removed, LSD ceased to produce hallucinatory phenomena (Baldwin et al. 1959; Serafintides, 1965)."
